The paper discussed the DOP building-up reactions condition and tested the influence of the heteropoly acid to supported conditions, the hydroxy-acid mole ratio, the catalyst amount, the reaction temperature and the reaction time, and the including water medicinal preparation amount on the esterification. 考察了杂多酸固载化条件、醇酸摩尔比、催化剂用量、反应温度、反应时间、带水剂用量对酯化反应的影响。